Organic synthesis : the disconnection approach
Organic compounds kurssikirja sähkökirjat
John Wiley & Sons Ltd.
2008
2nd ed.
EISBN 9781118681992
The disconnection approach.
Basic principles : synthons and reagents synthesis of aromatic compounds.
Strategy I : the order of events.
One-group C-X disconnections.
Strategy II : chemoselectivity.
Two-group C-X disconnections.
Strategy III : reversal of polarity, cyclisations, summary of strategy.
Amine synthesis.
Strategy IV : protecting groups.
One group C-C disconnections I : alcohols.
General strategy A : choosing a disconnection.
Strategy V : stereoselectivity A.
One group C-C disconnections II : carbonyl compounds.
Strategy VI : regioselectivity.
Alkene synthesis.
Strategy VII : use of acetylenes (alkines).
Two-group C-C disconnections I : Diels-Alder reactions.
Strategy VIII : introduction to carbonyl condensations.
Two-group C-C disconnections II : 1,3-difunctionalised compounds.
Strategy IX : control in carbonyl condensations.
Two-group C-C disconnections : 1,5-difunctionalised compounds.
Strategy X : aliphatic nitro compounds in synthesis.
Two-group disconnections IV : 1,2-difunctionalised compounds.
Strategy XI : radical reactions in synthesis.
Two-group disconnection V : 1,4-difunctionalised compounds.
Strategy XII : reconnection.
Two-group C-C disconnections VI : 1,6-diCarbonyl compounds.
General strategy B : strategy of carbonyl disconnections.
Strategy XIII : introduction to ring synthesis : saturated heterocycles.
Three-membered rings.
Strategy XIV : rearrangements in synthesis.
Four-membered rings : photochemistry in synthesis.
Strategy XV : the use of ketenes in synthesis.
Five-membered rings.
Strategy XVI : pericyclic reactions in synthesis : special methods for five-membered rings.
Six-membered rings.
General strategy C : strategy of ring synthesis.
Strategy XVII : stereoselectivity B.
Aromatic heterocycles.
General strategy D : advanced strategy.
Basic principles : synthons and reagents synthesis of aromatic compounds.
Strategy I : the order of events.
One-group C-X disconnections.
Strategy II : chemoselectivity.
Two-group C-X disconnections.
Strategy III : reversal of polarity, cyclisations, summary of strategy.
Amine synthesis.
Strategy IV : protecting groups.
One group C-C disconnections I : alcohols.
General strategy A : choosing a disconnection.
Strategy V : stereoselectivity A.
One group C-C disconnections II : carbonyl compounds.
Strategy VI : regioselectivity.
Alkene synthesis.
Strategy VII : use of acetylenes (alkines).
Two-group C-C disconnections I : Diels-Alder reactions.
Strategy VIII : introduction to carbonyl condensations.
Two-group C-C disconnections II : 1,3-difunctionalised compounds.
Strategy IX : control in carbonyl condensations.
Two-group C-C disconnections : 1,5-difunctionalised compounds.
Strategy X : aliphatic nitro compounds in synthesis.
Two-group disconnections IV : 1,2-difunctionalised compounds.
Strategy XI : radical reactions in synthesis.
Two-group disconnection V : 1,4-difunctionalised compounds.
Strategy XII : reconnection.
Two-group C-C disconnections VI : 1,6-diCarbonyl compounds.
General strategy B : strategy of carbonyl disconnections.
Strategy XIII : introduction to ring synthesis : saturated heterocycles.
Three-membered rings.
Strategy XIV : rearrangements in synthesis.
Four-membered rings : photochemistry in synthesis.
Strategy XV : the use of ketenes in synthesis.
Five-membered rings.
Strategy XVI : pericyclic reactions in synthesis : special methods for five-membered rings.
Six-membered rings.
General strategy C : strategy of ring synthesis.
Strategy XVII : stereoselectivity B.
Aromatic heterocycles.
General strategy D : advanced strategy.
